Values predictive of conversion to AD were; ApoC3< 105.5 μg/ml, TTR < 222 μg/ml, A1AT< 9.5 μg/ml, PEDF > 10.7 μg/ml, CC4 > 78.5 μg/ml, ICAM-1< 99.72 ng/ml, RANTES< 33.8 ng/ml, A1AcidG > 768.3 μg/ml, Cystatin C < 3.21 μg/ml, Clusterin > 402 μg/ml. The gene discussed is CST3; the disease is Alzheimer disease.