PIK3CA and neoplasm: The invasion and metastasis of tumor cells are influenced by the deregulation ofcomponents these same pathways, such as receptor tyrosine kinases (RTKs), and thedownstream phosphatidyl inositol 3-kinase (PI3K)-Akt kinase signaling pathways.Overwhelming evidence indicates that different miRNAs could regulate the abovepathways (see Figure 3).