Forinstance, fibronectin type III domain containing 3B (FNDC3B) regulates cell motility.In HCC, NF-kappaB can lead to the overexpression of miR-143, and miR-143 can targetFNDC3B, which could promote HCC invasion and metastasis by improving cell motility [[86]]. The gene discussed is FNDC3B; the disease is hepatocellular carcinoma.