For example, one group found that the genotypes of CT/CC in thers1057035 locus of the DICER gene could decrease the risk of HCC significantly whilethe AG/GG in the rs3803012 locus of the RAN gene might increase the risk of HCC.Thus, the combined effects of multi-gene alleles and multi-locus genotypes might havea synergistic role in the carcinogenesis of liver cancer [[32]]. Here, RAN is linked to hepatocellular carcinoma.