The mammary tumors that develop in MMTV/PyMT female mice recapitulate the histological stages of human breast cancer from premalignant lesions to invasive carcinoma [17] and they also display activation of the same signaling pathways that act downstream of the ErbB2 oncogene and are often activated in breast cancer, such as c-Src, PI3K and Ras [18]. This evidence concerns the gene ERBB2 and breast carcinoma.