The unique role of these receptors was proposed in preclinical models of cognitive disturbances of schizophrenia for atypical neuroleptics (APD) known to have agonist activity at the 5-HT1A receptor (e.g., risperidon and lurasidone) (Nagai et al. 2009; Snigdha et al. 2011; Horiguchi and Meltzer 2013; Horiguchi et al. 2013). Here, HTR1A is linked to schizophrenia.