AKT1 and colonic neoplasm: To investigate whether KYNA affects signaling pathways in colon cancer cells, we studied phosphorylation status of Akt and other elements of PI3K/Akt pathway, phosphorylation of ERK 1/2 and p38 kinases and protein expression of β-catenin in colon adenocarcinoma HT-29 cells treated with 1 mM concentration of KYNA for 5 min–48 h or treated with KYNA in the range of concentration 0.01–5 mM for 4, 24 and 48 h.