High PRDX1 expression was associated with low tumor grade (P <0.001), older age at diagnosis (P <0.001) and human epidermal growth factor receptor 2 (Her2) negativity (P = 0.001), while it displayed a borderline association with positive ER status (P = 0.05) (Table S2 in Additional file 2). Here, ESR1 is linked to neoplasm.