More recently, it has been demonstrated that Fam40b is located in the cytosol and is involved in the regulation of cell morphology of HeLa and PC3 prostate cancer cells.11 FAM40B-depleted HeLa or FAM40B-depleted PC3 cells appeared to detach from each other or to reduce migration, respectively.10, 11, 12 FAM40B depletion in PC3 cancer cells increased elongation of the cells, suggesting a potential role in the regulation of cytoskeletal organization and cell morphology.10, 11, 12 It has lately been recognized that the cytoskeletal organization is different in undifferentiated ESCs. This evidence concerns the gene STRIP2 and Familial prostate cancer.