STRIP2 and cancer: More recently, it has been demonstrated that Fam40b is located in the cytosol and is involved in the regulation of cell morphology of HeLa and PC3 prostate cancer cells.11 FAM40B-depleted HeLa or FAM40B-depleted PC3 cells appeared to detach from each other or to reduce migration, respectively.10, 11, 12 FAM40B depletion in PC3 cancer cells increased elongation of the cells, suggesting a potential role in the regulation of cytoskeletal organization and cell morphology.10, 11, 12 It has lately been recognized that the cytoskeletal organization is different in undifferentiated ESCs.