PGF and hypertensive disorder: For example, changes in circulating levels of angiogenic factors, such as placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and soluble endoglin (sEng) have been shown to occur prior to the onset of PE and cause phenotypic signs (e.g., hypertension proteinuria, glomerular endotheliosis) in animal models [2]–[7].