The DOR, sensitivity, specificity, positive likelihood (+LR) and negative likelihood (−LR) of GP210 in the diagnosis of PBC were 24.854 (11.957–51.660), 0.272(0.257–0.288), 0.985 (0.982–0.988), 17.874 (8.706–36.696), and 0.747 (0.696–0.802), respectively, and were 9.133 (4.739–17.600), 0.231 (0.213–0.249), 0.977 (0.973–0.981), 7.205 (3.884–13.366), and 0.805 (0.757–0.855), respectively, for SP100. This evidence concerns the gene SP100 and primary biliary cholangitis.