Among these, two subtypes of ANA, one that recognizes nuclear pore membrane protein gp210 (GP210) and another against nuclear body protein sp100 (SP100), have been reported to have a sensitivity of 15–40% [4]–[6] and 20–40% [4], [7], [8], respectively, whereas specificities of both GP210 and SP100 to PBC are greater than 95% [4], [5], [9]. The gene discussed is SP100; the disease is primary biliary cholangitis.