SOX11 and coloboma: In contrast, when the half dose of sox11 MO was combined with purmorphamine, the prevalence of lens malformations at 24 hpf and coloboma at 2 dpf significantly increased (sox11 MO half dose + purmorphamine: 57.9±10.2% malformed lens, 57.2±5.3% coloboma; sox11 MO half dose + DMSO: 24.2±3.5% malformed lens, 28.9±5.9% coloboma; p<0.0001; Figures 5B and S4A).