SOX11 and coloboma: We found that co-injection of bmp7b mRNA into sox11 morphants significantly reduced the number of embryos displaying ocular phenotypes (sox11 MO: 72.6±2.22% malformed lens, 74.5±1.8% coloboma; sox11 MO + bmp7b mRNA: 35.6±6.9% malformed lens; 43.8±14.4% coloboma; p<0.001; Figure 7B, C), although the rescue was not as large as that observed with cyclopamine treatment.