SOX11 and coloboma: The proportion of embryos displaying a malformed lens at 24 hpf (21.3±8.8%) or coloboma at 2 dpf (10.1±3.8%) was significantly reduced after cyclopamine treatment, compared to vehicle-treated sox11 morphants (>70% for both phenotypes; p<0.0001; Figures 5B and S4A).