Nevertheless, strain differences were noted for three different genes that cause absence seizures when mutated – Scn8a[14]), Gabrg2[15] and Gria4[16], and for at least two the C3H strain generally worsens the absence seizure phenotype, compared with the relatively protective strain C57BL/6J (B6J). The gene discussed is GRIA4; the disease is juvenile absence epilepsy.