Most of genes with lower expression from GSEA KEGG pathways play important roles in Jak-Stat and chemokine signaling (Table 3) and some of differentially expressed genes from the Leishmaniasis and Toxoplasmosis pathways belong to additional pro-inflammatory Toll-like receptor signaling pathway (Irak4, Mapk14, Stat1, Cd40, Pik3r3, Pik3cb, Akt3, Map2k6, Cxcl9, Tlr4, Traf6). The gene discussed is TLR4; the disease is leishmaniasis.