Importantly, mutations in Nesprin-1 and 2 are associated with numerous diseases including: autism [8], [9], cerebellar ataxia [10], Emery Dreifuss muscular dystrophy [11], cancer [12], arthrogryposis [13], and cardiomyopathy [14]. Here, SYNE1 is linked to Emery-Dreifuss muscular dystrophy.