Combined with our earlier observation that Brg1 is essential for stem cell maintenance in the small intestinal epithelium under the physiological conditions, these data may serve as a proof of concept that targeting the somatic stem cell as a cancer initiating cell may provide a valuable therapeutic approach, especially in the context of predisposition to Wnt-driven carcinogenesis, such as in Familial Adenomatous Polyposis patients. The gene discussed is SMARCA4; the disease is cancer.