Similar to the pattern observed in the small intestine of AhCreERT+Apcfl/flBrgfl/fl mice, adenomas in the small intestine of Lgr5-GFP-CreERT2+Apcfl/flBrgfl/fl mice retained Brg1 expression (Figure 4B) providing further support to the notion that Brg1 loss is incompatible with Wnt-driven adenoma formation. This evidence concerns the gene SMARCA4 and adenoma.