INS and type 2 diabetes mellitus: Using murine models of T2D, Trajkovski et al. demonstrated that miR-103 silencing improved glucose homeostasis, insulin sensitivity and decreased the amount of adipose tissue [4], while Takanabe et al. have found miR-143 levels associated with markers of adipocyte differentiation, and up-regulated in adipose tissue of high-fat diet-induced obese mice [5].