One possible explanation for the discrepancy between our data on CLR heterozygotes and the data regarding AM heterozygotes by Yamamoto et al is that the negative effects of CGRP signaling on asthma might be more potent than the protective effects of AM, and therefore diminished CGRP signaling may provide a greater benefit to airway resistance than the corresponding reduction in protective AM signaling. This evidence concerns the gene DCLK3 and asthma.