Contingency analysis of tumor phenotype and clinical features revealed significant, inverse associations of SSTR2 staining intensity with de-differentiation of tumors (as indicated by high Gleason grade, p<0.0001), advanced tumor stage of prostate cancers (as indicated by advanced pT category, p<0.0001, and cancer-positive surgical margins, p = 0.006) as well as high pre-operative PSA levels (p = 0.0011). The gene discussed is KLK3; the disease is Familial prostate cancer.