In pancreatic cancer the Src homology region 2 domain-containing tyrosine phosphatase 1 (SHP-1) is able to de-phosphorylate the epithelial cell adhesion molecule E-cadherin, thereby stabilizing inter-epithelial cell junctions in a SSTR2-dependent fashion [48], [50]. Here, CDH1 is linked to familial pancreatic carcinoma.