Reduced fertility, hypogonadism and testicular failure, which is a consequence of impaired gametogenesis, are also common [13], [14], and this is reflected in most mouse models for FA, including knockouts for Fanca, Fancc, Fancd2, Fancf, Fancg, Fancl, Fancm, and Fancp, though Fancd1 is an exception [15]–[22]. The gene discussed is FANCM; the disease is hypogonadism.