TGFB1 and neoplasm: Tregs directly inhibit NKG2D-mediated NK cell cytotoxicity, effectively suppressing NK cell-mediated tumor rejection by a TGF-β dependent mechanism and independent of IL-10 and depletion of Tregs via NKG2D before NK cell activation markedly enhances NK cell-mediated suppression of tumor growth and metastases in animal studies [108].