The glioma-specific antigens used in recent preclinical or clinical studies showing potent antiglioma effect include IL-13Rα2, human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor variant III (EGFRvIII), and erythropoietin-producing hepatocellular carcinoma A2 (EphA2) [19–22, 51]. This evidence concerns the gene EPHA2 and central nervous system cancer.