Histological type, age, tumor diameter, existing lymph node metastasis, the number of the metastatic lymph nodes, the expression of estrogen receptor (ER) and progesterone receptor (PR), proliferative rate (Ki-67), p53 mutation, and c-erbB-2 are oncogenic-prognostic determinants of breast carcinoma1-.3 Here, ESR1 is linked to metastatic malignant neoplasm in the lymph nodes.