Kai et al (20) reported a novel pathway of chromatin remodeling by resveratrol (Res) via the functional restriction of the MTA1/NuRD complex; Res decreased MTA1 expression, thus deregulating the MTA1/HDAC1 complexes leading to increased p53 acetylation (Ac-p53), and enhanced binding to the p21 and Bax promoters in the PCa cells. This evidence concerns the gene BAX and posterior cortical atrophy.