The expression of STAT-3 was observed and the correlation between tumor metastasis, invasion, angiogenesis and immune escape, and the expression of the matrix metalloproteinase (MMP)-10, vascular endothelial growth factor (VEGF), kinase insert domain receptor (KDR), hypoxia inducible factor (HIF)-1α, basic fibroblast growth factor (bFGF) and IL-10 proteins was investigated. Here, HIF1A is linked to neoplasm.