The AEG-1/MTDH gene consists of 12 exons/11 introns, as identified through the use of a genomic BLAST search (http://blast.ncbi.nlm.nih.gov/Blast.cgi), and is located at 8q22 where cytogenetic analysis of human gliomas suggests recurrent amplification (9). Here, MTDH is linked to glioma.