The positive expression of AEG-1/MTDH and SND1 is an independent poor prognostic predictor in colon cancer, as observed by multivariate Cox regression analysis, and the increased expression of AEG-1/MTDH and/or SND1 is closely associated with the carcinogenesis, progression and prognosis of colon cancer (78). Here, MTDH is linked to malignant colon neoplasm.