MTDH and hepatocellular carcinoma: In human HCC cells, the gene expression profiles of overexpressed AEG-1/MTDH have been identified in several drug-metabolizing enzymes involved in chemoresistance, including dihydropyrimidine dehydrogenase, cytochrome P450B6, dihydrodiol dehydrogenase, ATP-binding cassette transporter 11/MRP8 and transcription factor LSF/TFCP2 (15).