MTDH and malignant glioma: In malignant glioma cells, AEG-1/MTDH regulates invasion and migration through activation of the NF-κB signaling pathway (30), in which AEG-1/MTDH is involved in the lipopolysaccharide (LPS)-induced inflammatory response (31) and mediates the LPS-induced migration and invasion of breast cancer cells (32).