In gallbladder adenocarcinoma, the positive expression of EphA7 and AEG-1/MTDH has been found to significantly correlate with differentiation, tumor masses, lymph node metastasis, invasion and OS, and is an independent poor prognostic predictor, as determined by multivariate analysis (82). Here, MTDH is linked to metastatic malignant neoplasm in the lymph nodes.