MTDH and breast cancer: Silencing AEG-1/MTDH expression by RNA interference was found to effectively reduce metastasis by 3- to 10-fold in a MDA-MB-231 xenograft model of breast cancer lung metastasis, and it was also shown to sensitize chemoresistant MDA-MB-231 breast tumors to paclitaxel or doxorubicin (16).