MTDH and central nervous system cancer: In keeping with the role of AEG-1/MTDH in a number of different aspects of malignancy, AEG-1/MTDH has been found to correlate with tumor progression and poor prognosis in a number of cancer types, including HCC (17,53–58) and breast (59–64), prostate (65–67), glioma (68–70) and esophageal cancer (71) (Table I).