GTS-21, also known as DMBX-anabaseine, is a selective α7nAChR agonist that has been demonstrated to inhibit serum tumor necrosis factor (TNF) and high-mobility group box 1 in a dose-dependent manner in mice with lethal endotoxemia and sepsis (7,8) and collagen-induced arthritis (9). This evidence concerns the gene TNF and Sepsis.