The mechanisms of zoledronic acid in the treatment of malignant tumor bone metastases include: i) inhibiting the maturation of osteoclasts; ii) restraining the gathering and functioning of osteoclasts; iii) reducing the production of cytokines (such as IL-6); iv) direct antitumor activity (restraining cell proliferation and increasing cell lysis; v) inhibiting tumor cell adhesion and infiltration in the bone matrix; and vi) antiangiogenic effects (23–25). The gene discussed is IL6; the disease is neoplasm.