Associations among PAR-2, interleukin-4 receptor (IL-4R), transforming growth factor (TGF)-β and thymic stromal lymphoprotein (TSLP) have already been investigated in bronchial asthma, chronic obstructive pulmonary disease (COPD) (10) and idiopathic lung fibrosis (11). Here, F2RL1 is linked to chronic obstructive pulmonary disease.