The renal CSE activity and endogenous H2S concentration in the renal tissue of the septic rabbits was observed in order to determine the association between kidney injury induced by urinary-derived sepsis and endogenous H2S. NaHS was used as a donor for H2S in order to observe the effect of exogenous H2S on kidney injury and NF-κB expression in renal tissue. This evidence concerns the gene NFKB1 and Sepsis.