Whilst most prior sources are able to obtain significant results for HRAS, MAP2K1, MAPK1, and RAF1, significant results for half the prior sources for CDK5 and MAPK3 they struggle to provide meaningful information for inference of gene interactions in the context of colorectal cancer with the remaining two knock-downs (MAP2K2 and NGFR). The gene discussed is MAPK3; the disease is colorectal cancer.