The allele C of the intronic SNP rs653178 at the ATXN2-SH2B3 locus on chromosome 12 was present more frequently in PAD cases (52%) than in controls (47%) with a resulting odds ratio (OR) of 1.23 (95% CI, 1.11–1.36, P = 5.59 × 10−5) in the discovery cohort (Table 2). The gene discussed is SH2B3; the disease is peripheral arterial disease.