In mice with genetic deletion of ACE2 on the C57BL/6 background, ACE2 deficiency was associated with only a modest increase in blood pressure (Gurley et al., 2006; Tikellis et al., 2012), but enhanced susceptibility to Ang II-induced hypertension (Gurley et al., 2006). The gene discussed is ACE2; the disease is hypertensive disorder.