Other studies have shown no change in blood pressure in ACE2 knock-out (KO) mice compared to control C57BL/6 (Tikellis et al., 2008; Shiota et al., 2010), but once diabetes was induced in ACE2 KO mice, hypertension did develop (Tikellis et al., 2008). The gene discussed is ACE2; the disease is hypertensive disorder.