ACE and hypertensive disorder: In experimental models, stimulation of angiotensin II type 2 receptor (AT2R) may counteract AT1R mediated effects either directly or by modulating AT1R signaling (Lemarie and Schiffrin, 2010; McCarthy et al., 2013) In man, therapeutic strategies that block RAS activation using ACE inhibitors or Ang II receptor blockers are first line therapy in hypertension and have beneficial effects on morbidity and mortality.