AGT and cardiac hypertrophy: For example, cardiac ACE2 gene transfer reduced blood pressure and attenuated cardiac hypertrophy and fibrosis in SHR, but had no effect in normotensive WKY rats (Diez-Freire et al., 2006), and intra-cardiac ACE2 overexpression protected from angiotensin II-induced cardiac hypertrophy and fibrosis, but had no effect in vehicle infused rats (Huentelman et al., 2005).