In a short-term kidney failure model of hypertension induced by subtotal nephrectomy (STNx), we reported organ specific regulation of ACE2 with increased plasma and cardiac ACE2 (Burchill et al., 2008; Velkoska et al., 2011), and decreased kidney ACE2 (Velkoska et al., 2010). This evidence concerns the gene ACE2 and Hypertension.