ACE2 and Hypertension: For example, monocyte-derived macrophage ACE2 activity in untreated hypertensive patients was not different to levels in normotensive individuals (Keidar et al., 2007), and in patients with ST-elevation myocardial infarction (n = 95), there was no association between ACE2 activity and hypertension (Ortiz-Perez et al., 2013).