Hypertension secondary to short term Ang II infusion (2 weeks) in SD rats resulted in decreased kidney cortical and medullary ACE2 protein (Prieto et al., 2011), although chronic Ang II infusion (4 weeks) in SD rats increased cardiac ACE2 expression with no change in kidney ACE2 (Meng et al., 2014). Here, AGT is linked to hypertensive disorder.