In a study that examined ACE2 expression in the kidneys of SHR and normotensive Wistar-Kyoto (WKY) rats at birth, 6 weeks and adulthood (Tikellis et al., 2006), kidney ACE2 expression fell with the onset of hypertension in SHR compared to WKY, and remained reduced in the adult SHR kidney (Tikellis et al., 2006). This evidence concerns the gene ACE2 and Hypertension.