CD4 and hemophilia: Decline seems to be proportional with the decrease of immunological functioning, especially when the CD4+ cell counts ≤200 (Riedel et al., 1992; Nichols et al., 2000; Blanchette et al., 2002), even though other studies have concluded that the decline is related to hemophilia per se (Hilgartner et al., 1993; Whitt et al., 1993; Loveland et al., 1994; Sirois et al., 1998).