EIF2AK3 and Parkinson disease: The eIF2alpha kinase (also known as PERK), whose inhibition was recently shown to attenuate neurodegeneration in prion-infected mice (Moreno et al., 2013), and AMP-activated protein kinase (AMPK), a major metabolic regulatory enzyme whose activation has been associated with neuroprotection in a number of PD models (Wu et al., 2011; Bayliss and Andrews, 2013; Dulovic et al., 2014; Li et al., 2014).