As LRRK2 is also expressed by glial cells in normal human brain (Miklossy et al., 2006) and in tissue culture, and its expression in glia is increased by interferon gamma (Gardet et al., 2010) and bacterial lipopolysaccharide (LPS; Moehle et al., 2012), the neuroinflammation prevalent in PD affected regions may promote the expression changes observed for LRRK2 specifically in microglia rather than neurons. Here, LRRK2 is linked to Parkinson disease.