The increase in catalytic kinase activity with LRRK2 mutations has led to the development of LRRK2 kinase inhibitors as potential PD therapeutics (Deng et al., 2012) and much interest has focused on determining the targets of LRRK2 kinase activity (Dzamko and Halliday, 2013). The gene discussed is LRRK2; the disease is Parkinson disease.