One such robust effect for LRRK2 kinase activity is to mediate the phosphorylation-dependent interaction of LRRK2 with isoforms of the 14-3-3 adaptor protein (Dzamko et al., 2010); however, consensus regarding the PD-relevant physiological functions of LRRK2 has remained largely elusive. Here, LRRK2 is linked to Parkinson disease.