The phosphorylation of LRRK2 is also implicated in mutation induced disease, as PD-associated mutations Asn1437His, Arg1441Cys, Arg1441Gly, Arg1441His, Tyr1699Cys, and Ile2020Thr all show decreased phosphorylation at the cellular phosphorylation sites Ser910/935/955/973. Here, LRRK2 is linked to Parkinson disease.