LRRK2 and Parkinson disease: Phosphorylation of the LRRK2 cellular sites is disrupted in the PD mutations Asn1437His, Arg1441Gly, Arg1441His, Tyr1699Cys, and Ile2020Thr (Nichols et al., 2010; Li et al., 2011; Doggett et al., 2012; Lobbestael et al., 2013), while at the same time exhibiting small or enhanced levels of kinase activity (Sheng et al., 2012).