ATC armed with anti-CD3 x anti-tumor associated antigen BiAbs exhibit high levels of specific cytotoxicity against tumor cells expressing Her2/neu[17,18,32], CD20[15], GD2[33], and EGFR[16,19] via redirected non-MHC-restricted perforin/granzyme-dependent killing. The gene discussed is PRF1; the disease is neoplasm.