By breeding hGFAP-Cre;Nf1+/−;p53fl/fl;Ptenfl/+ glioma-prone mice to a Nestin-∆Thymidine kinase-GFP transgenic mouse line, in which GFP+ NSCs and glioma stem cells (GSCs) can be specifically ablated by ganciclovir, they showed that survival is prolonged upon ganciclovir treatment. The gene discussed is NES; the disease is central nervous system cancer.