PD occurs most commonly as a sporadic form (95 %), while familial forms make up the remainder, involving mutations in an array of proteins that include PINK1, PARKIN, LRRK2, fbxo-7 and DJ-1 [29], although environmental factors such as chemicals, pesticides and metals may increase the risk of developing PD [30–32]. Here, FBXO7 is linked to Parkinson disease.