The fact that the response does recover partly after the end of therapy is promising as it suggests that IFN-α therapy has less deleterious effects on HIV-specific responses and that ART intensification using IFN-α could be used to eliminate the latent HIV reservoir and achieve better cure of HIV infection [25] in co-infected individuals without risk of developing severe immunodeficiency and/or opportunistic infections. This evidence concerns the gene IFNA1 and Immunodeficiency.