After investigating the distribution of three downregulated genes within pathways in cancer, we found that HSP90B1 was involved in promoting cell proliferation and evasion of apoptosis, ARAF (RAF) promoted sustained angiogenesis, and RUNX1 induced differentiation and conferred tumor cells with an insensitivity to anti-growth signals (Figure 6B). This evidence concerns the gene RUNX1 and neoplasm.