TNKS and colonic neoplasm: Other small molecules, such as Olaparib (AZD2281), XAV939, JW55 and JW74, block Wnt/β-catenin signaling in colon cancer cell lines by binding to tankyrase (TNKS) catalytic poly-ADP-ribose polymerase (PARP) domain, which results in dramatic stabilization of the Axin protein, thereby lead to increased β-catenin destruction [40].