PPARG and obesity due to melanocortin 4 receptor deficiency: Recently, PPARG has been studied as transcription factor involved in adipocyte differentiation and the functional potential to improve intramuscular fat deposition [40], while PPARA has been shown to regulate obesity by both increasing hepatic fatty acid oxidation and decreasing the levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia [41].