The relationship remained significant after further adjustment for smoking, DM, hypertension, coronary artery disease, cerebrovascular disease, LVH, systolic and diastolic blood pressure, BMI, albumin, fasting glucose, log triglycerides, total cholesterol, hemoglobin, baseline eGFR, calcium-phosphorus product, uric acid, and proteinuria (HR, 1.020; 95% CI, 1.009–1.032; P<0.001). The gene discussed is ALB; the disease is hypertensive disorder.