This remarkable validation suggested that miR-124, miR-210, miR-381, miR-455-3p, miR-501-5p, miR-660 and miR-874, as well as STAT3, PSD4, SNF480, FGD6, EZH1, TRIM44, TBRG1, NFATC2IP and CA5B target-genes could possibly explain molecular mechanisms involved in BC carcinogenesis that distinguished tumors from familial to sporadic BC in young patients BRAC1/2 non carriers mutations. The gene discussed is EZH1; the disease is breast cancer.