For example, down-regulation of miR-29a, miR-29b and miR-29c in patients with balanced 11q23 translocations versus all other AML patients have been reported [31], while miR-29a and miR-29c were upregulated in AML with a good prognosis, such as NPMc+AML (aberrant cytoplasmic NPM1 localization) compared with NPMc− (unmutated) AML which is with a bad prognosis [32]. This evidence concerns the gene NPM1 and acute myeloid leukemia.