Down-regulated miR-29a and miR-29b associated with up-regulated Bcl-2 and Mcl-1 in myeloid leukemias indicate that miR-29a/miR-29b may contribute to the anti-apoptosis of myeloid leukemia cells according to binding with 3’-UTR of Bcl-2 and Mcl-1 genes, further investigations will focus on the function of miR-29a and miR-29b in myeloid leukemia and their interaction with Bcl-2 and Mcl-1. This evidence concerns the gene MCL1 and myeloid leukemia.