Given the lack of studies, the fixed-effect NMA provides the most robust estimates (Table 3), and indicates that the odds of hypoglycaemia for placebo were similar to dapagliflozin and DPP-4 inhibitor add-on treatment, but significantly greater than placebo for GLP-1 analogue add-on treatment (10.89 [95% CrI: 4.24, 38.28]). This evidence concerns the gene DPP4 and Hypoglycemia.