The immunohistochemical expression of HLTF was investigated in a series of normal thyroid tissue as well as in benign and malignant lesions, more specifically, 4 normal thyroid tissue (N), 10 colloid nodules (CN), 16 adenomas (Ad), 7 Hashimoto’s thyroiditis (HT), 7 Grave’s disease (GD), 17 papillary carcinomas (PC) and 12 follicular variant of papillary carcinomas (FVPC). Here, HLTF is linked to pachyonychia congenita.