This may be due to the accelerating spread of HSV-1 in the cultures at this time point, leading first into a well-known evasion of apoptosis caused by the expression of typical HSV-1 antiapoptotic proteins gD, gJ, Us3, ICP27 and ICP4 until the infection nears its completion at 144 hours [8,19-21]. The gene discussed is PAEP; the disease is infection.