The multivariate analysis included the variables for which in univariate analysis, significant differences or differences at significance border in DFS were seen, i.e. grade, hormone receptors status, CK5/6 expression, Ki-67LI, TOPOIIαLI, MVD, P53LI, BCL-2 expression and breast cancer immunophenotypes. The gene discussed is BCL2; the disease is breast carcinoma.