The overall low frequency of the BRAF-V600E mutation and serrated adenomas in this unique ethnic group of Saudi colorectal cancer cases suggests a very small role of the BRAF gene in the development of CRC and raises some interesting future questions on the burden of familial colorectal cancers like Hereditary non polyposis colorectal cancer cancer(HNPCC) syndrome in Saudi Arabia. The gene discussed is BRAF; the disease is colorectal cancer.