MTOR and Epileptic encephalopathy: Interestingly, mutations have been recently shown in an mTORC1 interacting protein, DEPDC5, in patients with malformations and epilepsy, as well as non-lesional epilepsy [33] and mTOR mutations have also been detected in epileptic encephalopathies [34] implicating this pathway may be involved in varied epilepsies.