SAV1 and neoplasm: The key players in this pathway include MST, Ras-association domain family (RASSF) proteins and WW45 (the human orthologue of Salvador), which are tumour suppressors and play significant roles in the immune system and in cardiovascular function (Saucedo & Edgar, 2007 ▶; Harvey & Tapon, 2007 ▶; Ling et al., 2008 ▶).